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An innovative approach called spatial oncology has emerged, offering a novel lens to study cancers like Pancreatic Ductal Adenocarcinoma (PDAC) within their intricate 2D or 3D environments. With recent funding from Beatson, CRUK, and UoG, Nigel Jamieson embarks on his research project that aims to unravel the significance of tertiary lymphoid structures in PDAC progression while pioneering multi-centric spatial-omic methodologies.
This research will focus on the intricacies of spatial oncology, shedding light on its transformative potential in understanding the complex interplay between cancer cells and their surrounding tissue microenvironment. By elucidating the role of tertiary lymphoid structures, Jamieson's study seeks to provide vital insights into the molecular mechanisms driving PDAC and identify new therapeutic targets.
The grant has facilitated the acquisition of essential resources. From the cutting-edge CytAssist device and necessary consumables to tissue microarray construction and sequencing costs, every element is meticulously planned to optimise the study's outcomes.
Moreover, the implementation of a streamlined CytAssist VISIUM spatial transcriptomic workflow not only empowers this research project but also extends its benefits to numerous investigations undertaken across the Beatson Institute campus and School of Cancer Sciences. By analysing specimens obtained from patients managed at the West of Scotland Beatson Oncology Centre, this study fosters collaborative discoveries that could revolutionise the field of spatial oncology as a whole.
For more information about this project, Email: funding@beatsoncancercharity.org
For further enquiries call our funding team on 0141 212 0505.
